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Although the CD90 Thy-1 was proposed as biomarker of several tumors and cancer stem cells, the involvement of this molecule in the progression of hepatocellular carcinoma HCC and other less frequent hepatic neoplasms is still undefined. A total of 67 liver tumors were analyzed: 51 HCC, 6 cholangiocarcinoma and 10 hepatoblastoma. In all cases, paired tissue sample of both the tumor and cirrhotic liver was available. Hepatic tissue obtained in 12 healthy livers was used as control.
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BMC Cancer. DecemberCite as. The presence of tumor supporting cells in various cancer, including in hepatocellular carcinoma HCChas become an important target in the study of carcinogenesis.
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Hepatocellular carcinoma HCC is one of most common cancers and the second leading cause of cancer-related death worldwide [ 1 ]. The incidence of HCC is expected to increase in the future, especially in America and northern and central Europe where diabetes, obesity, and alcohol abuse represent the major risk factors [ 2 — 4 ]. The success of HCC treatment primarily depends on the time of diagnosis.
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