Avastin breast ca

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Disclosures: Ricardo H. Significant advances in the treatment of patients with breast cancer have been made in the past 10 years. The current systemic treatment of breast cancer is characterized by the discovery of multiple cancer targets leading to treatments that are more sophisticated and specific than conventional cytotoxic chemotherapy.

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Reversing course on a drug that was approved for the disease inU. Food and Drug Administration Commissioner Margaret Hamburg said subsequent research did not confirm hopes that Avastin would help patients with advanced breast cancer live longer or improve quality of life. The drug will remain on the market for other uses, such as treating types of colon, lung, kidney and brain cancer.

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What is bevacizumab? How does bevacizumab work? Who might be offered bevacizumab?

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The federal health agency said it was suspending authorization of Avastin — the brand name for the drug bevacizumab — for treating metastatic breast cancer. Metastatic cancer occurs when cancer spreads to other parts of the body. In Canada, Avastin was authorized, conditionally, to treat patients with metastatic breast cancer in February

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Avastin chemical name: bevacizumab is a targeted therapy that was approved by the U. Food and Drug Administration FDA in combination with Taxol chemical name: paclitaxel in February to treat people with metastatic HER2-negative breast cancer who haven't yet received chemotherapy for metastatic breast cancer. On Nov.

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Outline the data from clinical trials of bevacizumab conducted in patients with breast cancer. Discuss the interpretation of the phase III study of capecitabine alone or in combination with bevacizumab. Vascular endothelial growth factor VEGF has emerged as a key target for the treatment of cancer.

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The case of Avastin and metastatic breast cancer reminds us of that simple, unfortunate fact once again. One of the most frustrating aspects of taking care of cancer patients is that in general, with only a few specific exceptions, we do not have good curative therapies for patients with stage IV cancer, particularly solid tumors. Over the years, we have thrown everything but the kitchen sink at patients with stage IV disease, largely with dissapointing results.

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The commissioner of the Food and Drug Administration on Friday revoked the approval of the drug Avastin as a treatment for breast cancerruling on an emotional issue that pitted the hopes of some desperate patients against the statistics of clinical trials. The commissioner, Dr. Margaret A. Hamburgsaid that clinical trials had shown that the drug was not helping breast cancer patients to live longer or to meaningfully control their tumorsbut did expose them to potentially serious side effects like severe high blood pressure and hemorrhaging.

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Saying that the available evidence does not show the drug to be safe or effective, the U. Food and Drug Administration today announced it is revoking its approval of bevacizumab for patients with metastatic breast cancer. The FDA voted to remove the indication for use of bevacizumab Avastin, Genentech for first-line treatment of HER2-negative metastatic breast cancer in combination with paclitaxel following 2 days of hearings in Junebut the final decision was up to FDA Commissioner Margaret A.

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The Genentech drug retains its indications for colon, lung, kidney, and brain cancer and will remain on the market. That meeting had been convened at Genentech's request to appeal the FDA's earlier decision to remove bevacizumab's breast cancer indication. After that meeting, Medicare said it would continue to pay for bevacizumab to treat metastatic breast cancer even if the FDA decides to remove that indication from the drug.


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